40+ years of the Cox model

Friday 8th March 2013

Event photos available online

Photos from the meeting can now be viewed at

http://csm.lshtm.ac.uk/previous-events/photos/

Overview

The British and Irish Region of the International Biometric Society, together with the Centre for Statistical Methodology at the London School of Hygiene and Tropical Medicine, announces a scientific meeting to mark 41 years of Sir David Cox's celebrated relative risk model for time-to-event data. The meeting will take place on 8 March 2013 in the John Snow (formerly Goldsmiths) Lecture Theatre at the London School of Hygiene and Tropical Medicine, where the "proportional hazards" paper was read before the Royal Statistical Society on 8 March 1972. The meeting will include presentations of novel research in event-history analysis, and a historical perspective on the impact of the paper.

Details

Date: 8 March 2013
Venue: John Snow Lecture Theatre, LSHTM, London

Costs

Registration costs £35 for IBS members, £20 for retired members and student members, and £50 for non-members of the society. The registration fee includes lunch, tea and coffee.

Posters

A limited number of posters describing research in event history analysis will be displayed during tea and lunch breaks. If you would like to contribute a poster, please send a title and abstract to Daniel Farewell (farewelld@cf.ac.uk) for consideration by the meeting committee.

Programme

 Document downloads for IBS members.
Join us now.
 
1100 - 1145The Cox model: introduction and history (Bianca De Stavola)

This talk will revisit the original 1972 paper, put the semi-parametric "Cox model" into the broader context of survival analysis as it was understood and practiced then, and how it is now. It will also discuss how partial likelihood— suggested in the 1972 paper and then formalized a few years later—addressed the inferential difficulties posed by this semi-parametric model. The enormous and continuing impact of this paper in applied research will be reviewed and the profound influence of its methodological insights celebrated.

Listen to & Watch Bianca's presentation (login to view)
 
1145 - 1200Questions and discussion
 
1200 - 1300Lunch
 
1300 - 1330Direct effects in survival analysis (Torben Martinussen)

We are interested in estimating the direct effect of an exposure variable X on a survival outcome T. In case of an intermediate variable K and an unobserved confounder U for the effect of K on T standard regression techniques will render a biased estimate of the direct effect of X on T. This problem may be solved with the inclusion of additional information, L, that removes the effect of U on K. However, if L is also affected by X then standard methods are still not appropriate. Marginal structural models have been suggested to tackle this problem but they need estimation of specific weights that may be quite unstable. To overcome this problem, Goetgeluk et al. (JRSSB, 2009) suggested a so-called G-estimation approach in the case of an un-censored response variable. In this talk I show how to generalize their approach to the setting of survival data. I will describe the methodology in detail for the Aalen additive hazards model and also give some calculations for the Cox model where it is more difficult to derive estimators.

Listen to & Watch Torben's presentation (login to view)
 
1330 - 1345Questions and discussion
 
1345 - 1415Parametric survival models (Paul Lambert)

The Cox model is the most popular method for the modelling of time-to-event data. The fact that it does not directly estimate the baseline hazard function is both an advantage and a disadvantage. I will describe flexible parametric alternatives to the Cox model. The flexibility comes from the use of restricted cubic splines to model the log cumulative hazard or the log hazard function. I will discuss situations where these parametric alternatives to the Cox model may be useful including modelling non-proportional hazards, modelling excess mortality (i.e. mortality above that expected in the general population), alternative ways to quantify differences between exposure groups and (iv) extrapolation of survival.

Listen to and Watch Paul's presentation (login to view)
 
1415 - 1430Questions and discussion
 
1430 - 1500Afternoon tea
 
1500 - 1530Another Look at Prediction and Explained Variation in Event History Analysis (Robin Henderson)

This talk revisits the related issues of prediction and explained variation for survival and more general event history data. There is no shortage of proposed measures of prognostic value for statistical models, especially proportional hazards, but none have been uniformly accepted and those in use in major computer packages may not be the most statistically meaningful. In this talk I review the issues and describe and illustrate use of a rank-based measure, developed in collaboration with Janez Stare and Maja Pohar, which is applicable and interpretable in discrete or continuous time, with tied data or otherwise, with time-varying, time-fixed or dynamic covariates, with time-varying or time-constant effects, with single or multiple event times, with parametric or semi-parametric models, and under general independent censoring/observation.

Listen to & Watch Robin's presentation (login to view)
 
1530 - 1545Questions and discussion
 
1545 - 1600Guest discussant: David Cox
Listen to the Discussion (login to view)
 
1600 - 1630Wine and open discussion
 

Download event flyer

Membership

Existing members can login below to view all site content. Lost password?

 
 

Other visitors might be interested to learn more about the benefits of membership.

Other events

18 Apr 18The Modern Bootstrap
28 Nov 17Celebrating Young Biometricians
23 May 17Statistical image analysis in medicine and biology
24 Apr 17 - 26 Apr 176th Channel Network Conference
10 Mar 17Exploiting publicly available genetic data

© 2009-2018 Biometric Society, British and Irish Region | Admin | Read our cookie and privacy policy